Diarrhea

Study results from Leiden University broaden understanding of diarrhea

Published in Pharma Investments, Ventures and Law Weekly, December 6th, 2009

"Danusertib (PHA-739358) is a small-molecule pan-aurora kinase inhibitor. This phase I dose escalation study was conducted to evaluate safety and tolerability of danusertib with additional pharmacokinetic, biomarker, and efficacy assessments," scientists in Netherlands report.

"Patients with solid tumors refractory to standard therapies or with no standard therapy available were enrolled. Danusertib was administered intravenously on days 1, 8, and 15 every 28 days in 6-hour or 3-hour infusion schedules (ie, 6-hour IVS or 3-hour IVS). Dose levels from 45 mg/m(2) in the 6-hour IVS, and from 250 mg/m(2) in the 3-hour IVS, were studied. Fifty patients were treated. For the...

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Source: Pharma Investments, Ventures and Law Weekly (2009-12-06)

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