Osteosarcoma

Studies from Baylor College of Medicine, College of Medicine reveal new findings on osteosarcoma

Published in Pharma Investments, Ventures and Law Weekly, December 13th, 2009

"Human epidermal growth factor receptor 2 (HER2) is expressed by the majority of human osteosarcomas and is a risk factor for poor outcome. Unlike breast cancer, osteosarcoma cells express HER2 at too low, a level for patients to benefit from HER2 monoclonal antibodies," scientists writing in the journal Molecular Therapy report.

"We reasoned that this limitation might be overcome by genetically modifying T cells with HER2-specific chimeric antigen receptors (CARs), because even a low frequency of receptor engagement could be sufficient to induce effector cell killing of the tumor. HER2-specific T cells were generated by retroviral transduction with a...

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Source: Pharma Investments, Ventures and Law Weekly (2009-12-13)

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