Broad Institute of Mit and Harvard
Gene mismatch influences success of bone marrow transplants
Published in Pharma Investments, Ventures and Law Weekly, December 13th, 2009
A commonly inherited gene deletion can increase the likelihood of immune complications following bone marrow transplantation, an international team of researchers reports in the November 22 advance online issue of Nature Genetics. When the gene, called UGT2B17, is missing from the donor's genome but present in the recipient's, transplants have a significantly greater risk of a serious side-effect known as graft-versus-host disease, in which immune cells from the donor attack tissues in the recipient.
"This finding gives us a glimpse into the genetic incompatibilities that can complicate transplants," said first author Steven McCarroll, an assistant professor at Harvard...
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