Newcastle General Hospital

DJ-1 gene polymorphism not linked to Parkinson disease

Published in Pharma Law Weekly, January 12th, 2004

A polymorphism in the human DJ-1 gene was not associated with sporadic dementia with Lewy bodies or Parkinson disease.

According to recent research published in the journal Neuroscience Letters, "Genetic analysis of early onset Parkinson disease (PD) has indicated that the mutation DJ-1 gene is one cause of autosomal recessive PD. Its role in the development of late onset PD and other Lewy body associated disorders such as dementia with Lewy bodies (DLB) is however unknown. We have therefore determined the influence of a common polymorphism in the DJ-1 gene that shows strong linkage disequilibrium with other DJ-1 polymorphisms, in late onset PD and DLB."

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Source: Pharma Law Weekly (2004-01-12)

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