Published in Pharma Law Weekly, April 20th, 2004
"Stress activates the hypothalamic-pituitary-adrenal axis through CRH, leading to production of glucocorticoids that downregulate immune responses," endocrinologists in Boston explained. "However, acute stress also has proinflammatory effects."
"We previously showed that restraint stress," like CRH and Ucn, "could activate mast cells and trigger mast cell-dependent vascular permeability," noted D. Kempuraj and coauthors at Tufts University.
In their subsequent study, the collaborators showed "for the first time...
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