Tufts University

Mast cells produce corticotropin-releasing hormone and urocortin

Published in Pharma Law Weekly, April 20th, 2004

Human mast cells produce and release corticotropin-releasing hormone (CRH) and the structurally related urocortin (Ucn).

"Stress activates the hypothalamic-pituitary-adrenal axis through CRH, leading to production of glucocorticoids that downregulate immune responses," endocrinologists in Boston explained. "However, acute stress also has proinflammatory effects."

"We previously showed that restraint stress," like CRH and Ucn, "could activate mast cells and trigger mast cell-dependent vascular permeability," noted D. Kempuraj and coauthors at Tufts University.

In their subsequent study, the collaborators showed "for the first time...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Pharma Law Weekly

Source: Pharma Law Weekly (2004-04-20)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry