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Corixa Corporation

Phase I trial of CRX-675 initiated in patients with seasonal allergic rhinitis

Published in Pharma Law Weekly, June 1st, 2004

Corixa Corporation (CRXA), a developer of immunotherapeutics, announced the initiation of a phase I clinical trial to test the safety and immune response activity of CRX-675 for seasonal allergic rhinitis (SAR).

The trial is being conducted in the United States under a U.S. Food and Drug Administration (FDA) Investigational New Drug Application (IND). CRX-675 is a member of Corixa's family of proprietary compounds that interact with toll-like receptor 4 (TLR4).

As a TLR4 agonist, CRX-675 may influence innate immunity, the body's first line of defense against a variety of infectious pathogens. TLR4 agonists can also affect the immune system's response...

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