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University of Melbourne

Chromosomal clustering defines the genetic character of forebrain structures

Published in Pharma Law Weekly, December 28th, 2004

Chromosomal clustering defines the genetic character of forebrain structures.

"The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to define these attributes in terms of their genetic activity, we have compared their genetic repertoires by using the Serial Analysis of Gene Expression database," said investigators in Australia.

"From a comparison of 78,784 hypothalamus tags with 125,296 neocortical tags, we demonstrate that each structure possesses a different transcriptional profile in terms of gene ontological...

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