Astex Technology

Patent covers use of crystal structure of human cytochrome P450 3A4

Published in Pharma Law Weekly, February 15th, 2005

Astex Technology, the fragment-based drug discovery and development company, announced issuance of patent GB2395718 covering the use of the crystal structure of human cytochrome P450 3A4, the most important drug metabolizing enzyme in man.

It is estimated that as many as 50% of all known drugs interact with this form of cytochrome P450 and as such it represents a major problem for drug developers.

Astex has been actively involved in human cytochrome P450 research since the company's formation and Astex scientists were the first group to successfully solve the crystal structures of human cytochromes P450, 3A4 and 2C9.

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Source: Pharma Law Weekly (2005-02-15)

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