Rockefeller University, New York
A key mu-opioid receptor gene polymorphism correlates with alcohol dependence
Published in Pharma Law Weekly, April 5th, 2005
According to a study from the United States, "the mu-opioid receptor (MOR), through its effects on reward and stress-responsivity, modulates alcohol intake in both animal and human laboratory studies."
"We have previously demonstrated that the frequently occurring A118G single-nucleotide polymorphism (SNP) in exon 1 of the MORgene (OPRM1), which encodes an amino-acid substitution, is functional and receptors encoded by the variant 118G allele bind the endogenous opioid peptide beta-endorphin with three-fold greater affinity than prototype receptors," said G. Bart and...
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Source: Pharma Law Weekly (2005-04-05)
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