Published in Pharma Law Weekly, April 5th, 2005
"Cellular senescence can be triggered by a variety of signals, including loss of telomeric integrity or intense oncogenic signaling, and is considered a potent, natural tumor suppressor mechanism. Previously, it was shown that the promyelocytic leukemia protein (PML) induces cellular senescence when overexpressed in primary human fibroblasts," researchers in France reported.
"The mechanism by which the PML W isoform elicits this irreversible growth arrest is believed to involve activation of the...
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