Yale University
RNA interference prevents West Nile virus infection in mice
Published in Pharma Law Weekly, April 26th, 2005
"West Nile virus causes fatal encephalitis in humans, mice, and other vertebrates. In the present study, we demonstrate that small interfering RNAs (siRNAs) inhibit West Nile virus replication in vitro," investigators in the United States report.
"Moreover, the administration of siRNAs to mice by hydrodynamic injection 24 hours before challenge with an intraperitoneal inoculum of West Nile virus reduced the viral load and afforded partial protection from lethal infection," wrote F.W. Bai and colleagues, Yale University, School of Medicine.
"These data show the efficacy...
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Source: Pharma Law Weekly (2005-04-26)
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