University of Marburg
Supramolecular gene delivery vectors excel at transfection
Published in Pharma Law Weekly, May 24th, 2005
According to published research from Germany, "soluble supramolecular inclusion complexes were formed by threading alpha-cyclodextrin (alpha-CD) molecules over poly(ethylene glycol) (PEG) and poly(E-caprolactone) (PCL) chains of ternary block copolymers of PEG, PCL and polyethylenimine (PEI)."
"Characteristic shifts of PCL absorptions in FTIR, H-1 NMR and UV spectra strongly suggest that alpha-CD is threaded over PEG and PCL blocks. Due to the reduced hydrophobic interaction between PCL blocks, the resulting supramolecular complexes displayed a dramatically increased solubility, in...
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Source: Pharma Law Weekly (2005-05-24)
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