Published in Pharma Law Weekly, May 24th, 2005
According to published research from Germany, "soluble supramolecular inclusion complexes were formed by threading alpha-cyclodextrin (alpha-CD) molecules over poly(ethylene glycol) (PEG) and poly(E-caprolactone) (PCL) chains of ternary block copolymers of PEG, PCL and polyethylenimine (PEI)."
"Characteristic shifts of PCL absorptions in FTIR, H-1 NMR and UV spectra strongly suggest that alpha-CD is threaded over PEG and PCL blocks. Due to the reduced hydrophobic interaction between PCL blocks, the resulting supramolecular complexes displayed a dramatically increased solubility, in...
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