Hokkaido University
Monoacylated MDP confers TLR2/TLR4 activation on dendritic cells
Published in Pharma Law Weekly, July 26th, 2005
"6-O-acyl-muramyldipeptides (MDP) with various lengths of fatty acid chains were examined for their dendritic cell (DC) maturation activity expressed through TLRs.
"Judging from anti-TLR mAb/inhibitor-blocking analysis, MDP derivatives with a single octanoyl or stearoyl fatty acid chain were found to activate TLR2 and TLR4 on human DCs, although intact and diacylated MDP expressed no ability to activate TLRs," scientists writing in the Journal of Immunology report.
"Human DC activation profiles by the monoacylated MDP were essentially similar to those by...
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Source: Pharma Law Weekly (2005-07-26)
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