Mayo Clinic

Genomics researchers discover protein deficit that causes drug toxicity

Published in Pharma Law Weekly, July 26th, 2005

Mayo Clinic researchers have discovered an inherited structural mechanism that can make drugs for some diseases toxic for some patients. The mechanism decreases a protein and in turn causes certain individuals to metabolize thiopurine drugs differently.

Thiopurine therapies are used to treat patients with childhood leukemia, autoimmune diseases and organ transplants. The Mayo researchers said their finding advances the field of pharmacogenomics, which tailors medicine to a patient's personal genetic makeup.

In Proceedings of the National Academy of Sciences, the researchers reported that...

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Source: Pharma Law Weekly (2005-07-26)

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