University of Cambridge
Emerging roles of apelin in biology and medicine reported
Published in Pharma Law Weekly, September 13th, 2005
"The family of apelin peptides is derived from a single gene and activates the 7-transmembrane G-protein-coupled receptor (GPCR) APJ. Apelins have been shown to be involved in the regulation of cardiovascular function and fluid homeostasis and interestingly represent substrates for ACE2, a carboxypeptidase recently described as a novel key enzyme in the renin-angiotensin-aldosterone system (RAS)," researchers in the United Kingdom reported.
"APJ has further been reported to be a coreceptor for the infection of CD4-positive cells with HIV in the central nervous system (CNS)....
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Source: Pharma Law Weekly (2005-09-13)
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