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Instituto Mexicano del Seguro Social, Guanajuato

Gln223arg polymorphism in leptin receptor gene linked to obesity traits

Published in Pharma Law Weekly, September 27th, 2005

The Gln223arg polymorphism in the human leptin receptor gene is associated with obesity traits in Mexican adolescents.

"Polymorphisms of leptin receptor (LEPR) may contribute to a common form of obesity and, as a consequence, obesity-related diseases. We evaluated the potential role of genetic variation at the LEPR gene in heart sympathetic activity and other traits related to obesity in Mexican adolescents. Adolescents aged between 12 and 17 years, with steady body weight for the last three months were included," scientists in Mexico report.

"We evaluated anthropometric measurements, blood pressure, serum glucose, insulin, leptin levels, heart...

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