Pune University
Complement regulatory domains identified in vaccinia virus complement control protein
Published in Pharma Law Weekly, November 22nd, 2005
According to a study from India, "Vaccinia virus encodes a homolog of the human complement regulators named vaccinia virus complement control protein (VCP). It is composed of four contiguous complement control protein (CCP) domains. Previously, VCP has been shown to bind to C3b and C4b and to inactivate the classical and alternative pathway C3 convertases by accelerating the decay of the classical pathway C3 convertase and (to a limited extent) the alternative pathway C3 convertase, as well as by supporting the factor I-mediated inactivation of C3b and C4b (the...
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Source: Pharma Law Weekly (2005-11-22)
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