Kagoshima University
Antibody conjugated with Pseudomonas exotoxin targets rheumatoid arthritis synovial macrophages
Published in Pharma Law Weekly, November 29th, 2005
Scientists in Japan conducted a study "to define the distribution of folate receptor beta (FR beta)-expressing cells in various tissues, including rheumatoid arthritis (RA) synovial tissues, and to verify the effects of an immunotoxin composed of an anti-FR beta monoclonal antibody (mAb) and truncated Pseudomonas exotoxin A (PEA) on apoptosis and tumor necrosis factor alpha (TNF alpha) production by adherent synovial mononuclear cells from RA patients."
"Anti-FRO mAb were produced by immunizing mice with...
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Source: Pharma Law Weekly (2005-11-29)
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