Wistar Inst of Anatomy & Biology, Philadelphia
Kaposi sarcoma-associated herpesvirus has immediate, early trans-inducing function
Published in Pharma Law Weekly, November 29th, 2005
According to recent research published in the Journal of Virology, "Lytic cycle reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) can be initiated by transcription activation of the ORF50 immediate-early (IE) gene promoter (ORF50p). We provide evidence that KSHV virions stimulate transcription of ORF50p."
"Virion activation was resistant to UV inactivation and cycloheximide treatment. The virion-responsive element was mapped to core promoter region -150 to + 1 relative to the ORF50 initiation codon."
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Source: Pharma Law Weekly (2005-11-29)
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