Northwestern University, Chicago
Cannabinoids inhibiting immune cell effector function may increase T. cruzi parasitemia
Published in Pharma Law Weekly, November 29th, 2005
"Trypanosoma cruzi invades heart cells via a calcium-dependent, G protein-mediated mechanism, leading to severe cardiac inflammation considered by some to be autoimmune in nature.
"Cannabinoids inhibit calcium flux and G protein signalling; as potent immunosuppressive agents, they are effective in the treatment of autoimmune disease but contraindicated for the treatment of infections," scientists writing in the journal Cellular Microbiology report.
Investigators compared "the action of the synthetic cannabinoid...
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Source: Pharma Law Weekly (2005-11-29)
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