Istituto Superiore di Sanita, Rome
HIV-1 Nef regulates superoxide anion release from macrophages
Published in Pharma Law Weekly, December 6th, 2005
According to recent research from Italy, "The NADPH oxidase enzymatic complex participates in the oxidative burst by producing ROS (reactive oxygen species). Altered levels of ROS production may have pathogenetic implications due to the loss of some innate immune functions such as oxidative burst and phagocytosis.
"Considering that HIV-1 Nef protein plays a primary role in AIDS pathogenesis, by affecting the immune system, we sought to dissect possible effects of Nef on the release of superoxide anions."
"We show here that the inducible expression of Nef in...
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Source: Pharma Law Weekly (2005-12-06)
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