M.D. Anderson Cancer Center

Galectin-3 modulates MUC2 mucin expression in human colon cancer cells

Published in Pharma Law Weekly, January 10th, 2006

According to recently published research from the United States, galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation.

"Galectin-3 and MUC2 intestinal mucin each have been correlated with the malignant behavior of colon cancer cells. Galectin-3 modulates expression of MUC2 protein, but the specific regulatory mechanisms are unknown," wrote S.M. Song and colleagues, M.D. Anderson Cancer Center.

"This study sought to determine how galectin-3 increases MUC2 expression. Galectin-3 levels in human colon cancer cells of high and low metastatic ability were manipulated via expression of...

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Source: Pharma Law Weekly (2006-01-10)

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