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Semmelweis University, Budapest

Th1 cell response for Hsp60 AA437-460 is more prominent in type 1 diabetes patients

Published in Pharma Law Weekly, January 10th, 2006

A significant shift towards the Th1 immune response was observed for heat shock protein 60 AA437-460 in type 1 diabetes mellitus patients.

According to a study from Hungary, "Type 1 diabetes mellitus (T1) is considered to be an immune mediated disease. Based on previous findings it might be suggested that heat shock protein 60 (Hsp60) could be involved in the mediation of the development of the disease. Furthermore a bias toward Th1 immune response was observed in T1D patients where the level of Th1 cytokines was elevated, while the level of Th2 was decreased."

A. Szebeni and colleagues at Semmelweis University proposed "[t]o determine Th1...

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