CHU Laval
Repeated effect of L-DOPA treatment reported to induce motor complications through gene regulation
Published in Pharma Law Weekly, January 17th, 2006
"Motor complications induced through repeated L-DOPA treatment in patients with Parkinson's disease are thought to be the consequence of molecular adaptations that occur in response to repeated dopamine receptors stimulation," wrote M. St-Hilaire and colleagues, CHU Laval.
"Here," the researchers report, "we studied the molecular changes taking place in the denervated striatum of unilaterally 6-OHDA-lesioned rats repeatedly treated with L-DOPA alone or combined to the D, receptor antagonist SCH23390.
"We looked at...
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Source: Pharma Law Weekly (2006-01-17)
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