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Boston Medical Center

Systemic inflammation effects on endothelium-dependent vasodilation are reviewed

Published in Pharma Law Weekly, March 21st, 2006

Experimental and clinical studies that support the relevance of inflammation to nitric oxide bioactivity in human atherosclerosis are reviewed in the journal Trends in Cardiovascular Medicine.

According to the review, "The importance of inflammation in the pathogenesis of atherosclerosis is well established. The vascular endothelium contributes to and is affected by the inflammatory process."

"For example," wrote A.L. Huang and J.A. Vita at Boston Medical Center, "a variety of cytokines have the ability to 'activate' the endothelium and thereby promote expression of adhesion molecules and chemotactic factors that accelerate the inflammatory...

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