University of Cincinnati
Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice
Published in Pharma Law Weekly, May 23rd, 2006
"Cardiac hypertrophy and dilation are mediated by neuro-endocrine factors and/or mitogens as well as through internal stretch- and stress-sensitive signaling pathways, which in turn transduce alterations in cardiac gene expression through specific signaling pathways. The transcription factor family known as myocyte enhancer factor 2(MEF2) has been implicated as a signal-responsive mediator of the cardiac transcriptional program. For example, known hypertrophic signaling pathways that utilize calcineurin, calmodulin-dependent protein kinase, and MAPKs can each affect MEF2...
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Source: Pharma Law Weekly (2006-05-23)
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