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Aarhus University, Denmark
IV injection for tumors resulted in a higher fraction of adoptively transferred cells
July 4th, 2006
IV injection for tumors resulted in a higher fraction of adoptively transferred cells with an activated phenotype. According to a study from Denmark, "Accumulation of T cells at the tumor is essential in cancer immunotherapy based on adoptive transfer of tumor-specific T cells. To gain further insight into the accumulation process and to evaluate the effect of using different routes of cell transfer, we investigated the accumulation of ovalbumin-specific CD8(+) T cells (OT-I) injected either intravenously (IV) or intraperitoneally (IP) into mice carrying a subcutaneous tumor of the ovalbumin-expressing melanoma cell line B16-OVA." "Maximal...
Source: Pharma Law Weekly (2006-07-04)
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