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Children's Medical Research Institute, Australia
MusTRD can regulate postnatal fiber-specific expression
July 4th, 2006
A study from Australia has reported that MusTRD can regulate postnatal fiber-specific expression. "Human MusTRD1 alpha 1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (ThIslow USE) and was predicted to be a regulator of slow fiber-specific genes," wrote L.L. Issa and colleagues, Children's Medical Research Institute. "To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1 alpha 1 in skeletal muscle." "Adult transgenic mice show a complete loss of slow fibers and a concomitant replacement by fast IIA fibers, resulting in postural muscle weakness. However,...
Source: Pharma Law Weekly (2006-07-04)
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