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Chiba University, Japan
Basal arterial BP, defense response mediated by orexin-containing neurons in perifornical area
July 4th, 2006
Orexin-containing neurons in the perifornical area act as a master switch to activate multiple efferent pathways of the defense response and also operate as a regulator of basal arterial blood pressure. According to a study from Japan, "We have previously shown that some features of the defense response, such as increases in arterial blood pressure (AP), heart rate (HR), and ventilation were attenuated in prepro-orexin knockout (ORX-KO) mice. Here, we examined whether the same was true in orexin neuron-ablated [orexin/ataxin-3 transgenic mice (ORX/ATX-Tg)] mice." "In addition," wrote Chiba University researchers W. Zhang and colleagues, "we examined...
Source: Pharma Law Weekly (2006-07-04)
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