Trudeau Institute, U.S.

Key elements of cellular immunity help protect against Yersinia pestis

Published in Pharma Law Weekly, July 25th, 2006

Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.

"Pulmonary infection by Yersinia pestis causes pneumonic plague, a rapidly progressing and often fatal disease. To aid the development of safe and effective pneumonic plague vaccines, we are deciphering mechanisms used by the immune system to protect against lethal pulmonary Y. pestis infection," researchers in the United States report.

"In murine pneumonic plague models, passive transfer of convalescent-phase...

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Source: Pharma Law Weekly (2006-07-25)

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