Research on hypertrophy genetics discussed by scientists at State University of New York

Current study results from the report, "Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy," have been published. According to a study from the United States, "We examined the role of Jak2 kinase phosphorylation in the development of pressure overload hypertrophy in mice subjected to transverse aortic constriction (TAC) and treated with tyrphostin AG490, a pharmacological inhibitor of Jak2. Control mice (sham), subjected to TAC for 15 days (TAC) or to TAC and treated with 48 microg/kg/day i.p. of tyrphostin AG490 (TAC+AG490) were evaluated for morphological, physiological, and molecular changes associated with pressure overload hypertrophy."

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