New findings from Slotervaart Hospital, Department of Pharmacy & Pharmacology in the area of candidiasis therapy described

A new study, "Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers," is now available. "Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates. This study was performed to assess the occurrence and frequency of DCK polymorphisms in a predominantly Caucasian population and to choose candidate polymorphisms for subsequent functionality studies. All seven DCK exons and the promoter region were sequenced from 100 healthy volunteers (79 females and 21 males)," investigators in...

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