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Pain Management

Alexza Pharmaceuticals announces initial results for the AZ-003 phase I clinical trial

Published in Pharma Law Weekly, January 23rd, 2007

Alexza Pharmaceuticals, Inc., (ALXA) has completed the enrollment of its phase I clinical trial with AZ-003 (Staccato fentanyl).

The company has also completed a preliminary analysis of the top-line results of the clinical trial. AZ-003 is an inhalation product candidate being developed for the treatment of patients with acute pain episodes, including patients with breakthrough pain and postoperative pain.

The phase I clinical trial was conducted in opioid naive healthy volunteers in two stages. In Stage 1, the arterial pharmacokinetics (PK) of 25 micrograms of AZ-003 was compared to a 25 micrograms dose of fentanyl administered intravenously (IV)....

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