Parkinson Disease

Data from K. Kashihara et al provide new insights into Parkinson disease

Published in Pharma Law Weekly, January 15th, 2008

"Long-term administration of levodopa in Parkinson's disease (PD) can cause motor complications such as dyskinesias and motor response fluctuations. An increased risk is associated with more severity and younger age at onset of PD, longer duration of treatment, and higher levodopa dose," researchers in Okayama, Japan report.

"Levodopa-induced dyskinesias (LID) consist of peak-dose dyskinesia, biphasic dyskinesia, and off-period dystonia. The pathophysiology of LID includes both pre- and post-synaptic mechanisms. Sensitized responsiveness of striatal dopamine D-1, D-2, and D-3 receptors caused by dopamine depletion might be involved in the development of LID. The...

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Source: Pharma Law Weekly (2008-01-15)

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