Amyotrophic Lateral Sclerosis

Findings from University of Pisa advance knowledge in amyotrophic lateral sclerosis

Published in Pharma Law Weekly, May 13th, 2008

According to a study from Pisa, Italy, "ALS is a devastating neurodegenerative disorder with no effective treatment. In the present study, we found that daily doses of lithium, leading to plasma levels ranging from 0.4 to 0.8 mEq/liter, delay disease progression in human patients affected by ALS."

"None of the patients treated with lithium died during the 15 months of the follow-up, and disease progression was markedly attenuated when compared with age-, disease duration-, and sex-matched control patients treated with riluzole for the same amount of time. In a parallel study on a genetic ALS animal model, the G93A mouse, we found a marked neuroprotection by lithium,...

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Source: Pharma Law Weekly (2008-05-13)

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