Life Sciences
New findings reported from University Complutense of Madrid describe advances in life sciences
Published in Pharma Law Weekly, October 21st, 2008
Investigators publish new data in the report 'The inhibition of release by mGlu7 receptors is independent of the Ca2+ channel type but associated to GABAB and adenosine A1 receptors.' "Neurotransmitter release is inhibited by G-protein coupled receptors (GPCRs) through signalling pathways that are negatively coupled to Ca2+ channels and adenylyl cyclase. Through Ca2+ imaging and immunocytochemistry, we have recently shown that adenosine A1, GABAB and the metabotropic glutamate type 7 receptors coexist in a subset of cerebrocortical nerve terminals," investigators in Madrid, Spain report.
"As these receptors inhibit glutamate release through common intracellular...
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Source: Pharma Law Weekly (2008-10-21)
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