Adenovirus

Research results from F. Vigant and colleagues update understanding of adenovirus

Published in Pharma Law Weekly, October 21st, 2008

According to a study from Villejuif, France, "Liver tropism potentially leading to massive hepatocyte transduction and hepatotoxicity still represents a major drawback to adenovirus (Ad)-based gene therapy. We previously demonstrated that substitution of the hexon hypervariable region 5 (HVR5), the most abundant capsid protein, constituted a valuable platform for efficient Ad retargeting."

"The use of different mouse strains revealed that HVR5 substitution also led to dramatically less adenovirus liver transduction and associated toxicity, whereas HVR5-modified Ad were still able to transduce different cell lines efficiently, including primary hepatocytes. We showed...

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Source: Pharma Law Weekly (2008-10-21)

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