Published in Pharma Law Weekly, October 21st, 2008
"Stabilization of the cleavage complex is necessary but not sufficient for cell killing-cytotoxicity apparently results from the conversion of cleavage complexes into overt DNA breaks by an as-yet-unknown mechanism(s). Quinolone treatment induces the bacterial SOS response in a RecBC-dependent manner, arguing that cleavage complexes are somehow converted into double-stranded...
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