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Studies from Osaka University, Institute for Protein Research further understanding of life sciences

Published in Pharma Law Weekly, December 2nd, 2008

New investigation results, 'Biphasic effects of orexin-A on autonomic nerve activity and lipolysis,' are detailed in a study published in Neuroscience Letters. "Previously, we showed that orexin-A, a 33-aa peptide, influences renal sympathetic nerve activity. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects of orexin-A on the sympathetic nerve activity innervating white adipose tissue (WAT-SNA) and lipolysis," investigators in Suita, Japan report.

"We found that intracerebroventricular (icv) administration of orexin-A at doses of 1 microg/rat and 10 ng/rat elevated and...

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