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Temporomandibular Joint Dysfunction Syndrome Animal Studies

Studies from University of Minnesota yield new data on temporomandibular joint dysfunction syndrome animal studies

Published in Pharma Law Weekly, December 2nd, 2008

Investigators publish new data in the report 'Estradiol replacement modifies c-fos expression at the spinomedullary junction evoked by temporomandibular joint stimulation in ovariectomized female rats.' "The influence of estradiol (E2) treatment on temporomandibular joint (TMJ) nociceptive processing in the caudal trigeminal sensory brain stem complex was assessed in ovariectomized female rats by quantitative Fos-immunoreactivity (Fos-LI). After 2 days of daily injections of high (HE2) or low (LE2) dose E2 rats were anesthetized and the small fiber excitant, mustard oil (MO, 0-20%), was injected into the TMJ and after 2 h brains were processed for Fos-LI," scientists writing in the journal...

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