Pharmacokinetics

Research from H.M. Faessel and co-authors yields new data on pharmacokinetics

Published in Pharma Law Weekly, December 16th, 2008

According to a study from the United States, " This study investigated the effect of varenicline on the multiple-dose pharmacokinetics of digoxin. Eighteen smokers were randomized to receive digoxin (Lanoxicaps (R) 0.2 mg QD) with varenicline 1 mg BID or placebo for 14 days."

" Varenicline had no clinically relevant effect on the digoxin steady-state exposure, as evidenced by the 90% confidence intervals for the ratios of AUC(0-24) (87.5-108%) and C-min (83.8-116%) wholly contained within 80-125%. Digoxin C-max and T-max remained unchanged in the presence of varenicline, consistent with no apparent alteration in digoxin bioavailability. A minimal 11.3% increase in...

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Source: Pharma Law Weekly (2008-12-16)

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