Pharmacokinetics
Research results from T. Viel and co-authors update knowledge of pharmacokinetics
Published in Pharma Law Weekly, December 23rd, 2008
"Molecular imaging was used to study the biodistribution, pharmacokinetics, and activity of naked small interfering RNAs (siRNAs). siRNAs with riboses chemically modified in the 2' position were compared with unmodified siRNA. In vitro, replacement of the 2'-hydroxyl (2'OH) group of certain nucleotides in an siRNA sequence by a fluorine atom (2' F) on both antisense (AS) and sense (S) strands [2'F(AS/S)], or by a methoxy group (2' OMe) on the S strand [2'OH(AS)/2'OMe(S)], was compatible with RNA interference," scientists writing in the journal Oligonucleotides report.
"Different siRNAs [2'F(AS/S), 2'OH(AS)/2'OMe(S), and 2'OH(AS/S)] were labeled with fluorine- 18...
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Source: Pharma Law Weekly (2008-12-23)
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