Drug Resistance

Studies from Southern Medical University provide new data on drug resistance

Published in Pharma Law Weekly, December 23rd, 2008

According to a study from Guangzhou, People's Republic of China, "High resistance to drug is taken as a characteristic of human tumors, which is usually mediated by multidrug resistance-associated genes. ABCC2, an ATP-binding cassette multidrug resistance transporter, is found to be expressed in a variety of human cancers."

"In this study the effect of a RNAi construct targeting ABCC2 on the chemosensitivity of NPC cell line CNE2 against cisplatin was investigated. Lentiviral vectors were constructed to allow an efficient expression of anti-ABCC2 siRNA. The effective target sequence comprised nucleotides 1707-1727 of the human ABCC2 mRNA. The cell clones expressing the...

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Source: Pharma Law Weekly (2008-12-23)

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