Therapy

Data on therapy discussed by researchers at Wayne State University

Published in Pharma Law Weekly, April 28th, 2009

"The therapeutic usefulness of the quinoxaline derivatives XK469 (2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid) and SH80 (2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid) has been attributed to their abilities to induce G(2)/M arrest and apoptotic or autophagic cell death. Concentrations of XK469 or SH80 >= 5 mc M were cytostatic to cultures of the normal murine melanocyte cell line Melan-a," scientists in the United States report.

"Higher concentrations caused dose-dependent cytotoxicity. Concentrations >= 10 mc M provoked dramatic morphological changes typified by marked increases in cell size and granularity. XK469/SH80-treated cultures...

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Source: Pharma Law Weekly (2009-04-28)

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