Life Sciences

Reports from T. Ekblad et al highlight recent research in life sciences

Published in Pharma Law Weekly, June 2nd, 2009

According to a study from Stockholm, Sweden, "The human epidermal growth factor receptor HER2 has emerged as an important target for molecular imaging of breast cancer. This article presents the design and synthesis of a HER2-targeting affibody molecule with improved stability and tumor targeting capacity and with potential use as an imaging agent."

"The 58 aa three-helix bundle protein was assembled using solid-phase peptide synthesis, and a chemoselective ligation strategy was used to establish an intramolecular thioether bond between the side chain thiol group of a cysteine residue, positioned in the loop between helices I and II, and a chloroacetyl group on the side...

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Source: Pharma Law Weekly (2009-06-02)

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