Atherosclerosis
Studies from Louisiana State University describe new findings in atherosclerosis
Published in Pharma Law Weekly, June 2nd, 2009
"We recently showed that poly(ADP-ribose) polymerase (PARP) is activated within atherosclerotic plaques in an animal model of atherosclerosis. Pharmacological inhibition of PARP or reduced expression in heterozygous animals interferes with atherogenesis and may promote factors of plaque stability, possibly reflecting changes in inflammatory and cellular factors consistent with plaque stability," scientists writing in the Journal of Pharmacology and Experimental Therapeutics report.
"The current study addresses the hypothesis that pharmacological inhibition of PARP promotes atherosclerotic plaque regression. Using a high-fat dietinduced atherosclerosis...
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Source: Pharma Law Weekly (2009-06-02)
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