Pharmaceuticals
Research reports on pharmaceuticals from P. Han and colleagues provide new insights
Published in Pharma Law Weekly, July 14th, 2009
"This study explored how study design influences the probability of selecting a 'true' covariate from two competing covariate models. The probability of selecting the 'True Model' (lean body weight on clearance) over the 'False Model' (total body weight (WT) on clearance) was compared for designs where WT was either lognormally distributed (i.e. non-stratified), or stratified into 3 equal strata," scientists in Brisbane, Australia report.
"The probability of selecting the 'True Model' increased as the WT inclusion criterion widened, and was always greater under the stratified design. Incorporating stratification into study designs, in combination with a wide covariate...
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Source: Pharma Law Weekly (2009-07-14)
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