Cancer
Findings from D. Packham et al in cancer reported
Published in Pharma Law Weekly, July 14th, 2009
According to a study from Australia, "Activating mutations of the BRAF and KRAS genes cause constitutive stimulation of an important cell-signaling pathway promoting tumorigenesis, and are increasingly recognized as determinants of response to targeted cancer therapies. The V600E mutation accounts for most of the BRAF mutations in cancer, and KRAS mutations are predominantly encoded by nucleotide substitutions within codons 12 and 13."
"We designed novel pyrosequencirig assays for the detection of the common ''hotspot'' mutations in these genes, which demonstrated analytical sensitivities of <= 10% in titrations of mutant cell lines. The KRAS pyrosequencing assay has...
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Source: Pharma Law Weekly (2009-07-14)
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