Cancer Gene Therapy

New cancer gene therapy research from M. Idogawa and colleagues discussed

Published in Pharma Law Weekly, July 21st, 2009

"Gene transfer involving p53 is viewed as a potentially effective cancer therapy, but does not result in a good therapeutic response in all human cancers. The activation of p53 induces either cell cycle arrest or apoptosis," scientists in Sapporo, Japan report.

"Cell cycle arrest in response to p53 activation is mediated primarily through the induction of the cyclin-dependent kinase inhibitor p21. Because p21 also has an inhibitory effect on p53-mediated apoptosis, the suppression of p53-induced p21 expression would be expected to result in the preferential induction of apoptosis. However, p21 also has tumor-suppressive properties. In this study, we developed an...

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Source: Pharma Law Weekly (2009-07-21)

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