Published in Pharma Law Weekly, September 1st, 2009
"Unfortunately, experimental structure data for plasmodial GSK-3 is not yet available. Homology building can be used to generate such three-dimensional structure data using structure information of a homologous protein. GSK-3 possesses a very flexible ATP-binding site, a fact reflected in the variety of X-ray structures of the human GSK-3 beta which are deposited in the protein data base and are crystallized with different ligands. We used ten different HsGSK-3...
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